1. Director, Human Research Protection Center, Cardinal Tien Hospital
2. Chief Information Security Officer (CISO), Cardinal Tien Hospital
3. Chief Sustainability Officer (CSO), Cardinal Tien Hospital
4. Associate Professor, School of Medicine, College of Medicine, Fu Jen Catholic University
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1. Lin CP, Hsu WC, Wang GL, Su HC, Chung HC, Hung SH, Chen MC, Chen JW, Wang PC. Factors associated with attainment of ad hoc entrustability among Taiwan otolaryngology resident physicians: a nationwide cross-sectional study. BMC Med Educ. 2025;25(1):1135. (Corresponding Author)
2. Lin YS, Chen JW, Chang WW. Enhancing healthcare education: Validation of the traditional chinese EQual rubric for effective assessment of entrustable professional activities. Nurse Educ Pract. 2025;87:104463. (Co-First Author)
3. Lai KY, Lin HC, Shih WT, Chien WC, Chung CH, Chen MC, Chen JW, Chung HC. Association of Increased Risk of Injury in Adults With Hearing Loss: A Population-Based Cohort Study. Trends Hear. 2025;29:23312165241309589. (Corresponding Author)
4. Hsu HW, Huang SH, Lee SH, Lin ST, Chen MC, Yang RY, Lee SD, Chen JW. Impact of Intraoperative Interventions on Hypocalcemia Post-Total Thyroidectomy: A Meta-Analysis. J Otolaryngol Head Neck Surg. 2025;54:19160216251333355. (Corresponding Author)
5. Guo FC, Chen YT, Hsu WC, Wang PC, Chen MC, Chen JW. EMYWAY Workplace-Based Entrustable Professional Activities Assessments in Otolaryngology Residency Training: A Nationwide Experience. Otolaryngol Head Neck Surg. 2025;172(4):1242-53. (Corresponding Author)
6. Yu RB, Chen YJ, Chang CH, Chen YL, Chen JW. Kikuchi-Fujimoto Disease Associated With Mycoplasma Pneumoniae Infection. Ear Nose Throat J. 2024;103(4):NP223-NP5. (Corresponding Author)
7. Ontimare Manlises C, Chen JW, Huang CC. A gated recurrent unit model based on ultrasound images of dynamic tongue movement for determining the severity of obstructive sleep apnea. Ultrasonics. 2024;141:107320.
8. Mao JJ, Lin HC, Lin ST, Lin PC, Chang CH, Chien WC, Chung CH, Chen YJ, Chen JW. Incidence of Subsequent Injuries Associated with a New Diagnosis of Benign Paroxysmal Positional Vertigo and Effects of Treatment: A Nationwide Cohort Study. J Clin Med. 2024;13(15). (Corresponding Author)
9. Cho HC, Chang CH, Lin ST, Chen JW. Assessment of Entrustable Professional Activities by Using the EMYWAY Competency Progression Platform in the Context of Otorhinolaryngology–Head and Neck Surgery—A Case Study at a Single Teaching Hospital. J Taiwan Otolaryngol Head Neck Surg. 2024;59(1):8-16. (Corresponding Author)
10. Chen PH, Lin KN, Lin HY, Yu RB, Liu PY, Shih WT, Chen JW. Factors Associated With Hearing Outcomes After Stapedotomy in Taiwanese Patients With Clinical Otosclerosis. Ear Nose Throat J. 2024;103(2):NP76-NP84. (Corresponding Author) |
This lecture explores innovations in obstructive sleep apnea (OSA) management, from diagnosis to non-invasive therapeutic strategies.
The first segment will highlight significant progress in large-scale sleep database studies utilizing deep neural networks. A key advantage is the use of unsegmented peripheral oxygen saturation (SpO2) and electrocardiography (ECG) signals from extensive public datasets for OSA severity classification and apnea-hypopnea index (AHI) prediction. This approach eliminates the labor-intensive requirement for signal segmentation and annotation, greatly enhancing classification efficiency. SpO2-based models have achieved high accuracies, exceeding 91% for two-level classification and reaching up to 81.13% for four-level AHI prediction. ECG-based models have shown up to 59.49% accuracy for four-level classification and a correlation coefficient of 0.83 for AHI prediction.
The second part will focus on basic research in ultrasound neuromodulation, presenting low-intensity pulsed ultrasound (LIPUS) as a promising non-invasive therapeutic method. In vitro studies demonstrate LIPUS’s neuroprotective effects by mitigating endoplasmic reticulum (ER) and oxidative stress, preserving mitochondrial function, and inhibiting apoptosis. This is mediated by LIPUS-induced calcium influx through mechanosensitive channels, activating critical transcription factors (NFAT, NF-κB) and the AKT pathway, promoting cell survival. In vivo animal studies show LIPUS application to the hypoglossal nerve (HN) significantly enhances genioglossus muscle (GM) activity and improves oxygen saturation. Real-time US imaging confirmed direct tongue movement, and comprehensive safety assessments found no thermal damage or adverse effects on nerve or tissue. These advancements hold potential for more accessible, efficient, and safer OSA diagnostics and treatments.
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