講師資料
Talks：
Hypersomnolence, Narcolepsy and Idiopathic Hypersomnia: Mechanisms and Implications for Precision Medicine
Name：
Prof. Yves Dauvilliers (France)
Position：
Professor of Neurology and Physiology at the University of Montpellier, France
Member of the Scientific board of the Medical University of Montpellier
Coordinator of Fédération Hospitalo-Universitaire Neuroscience « NEUROCLIN»
Member of governance of Brainteam (Filière nationale de Soins) and of the COEN of Montpellier
Coordinator of Team : Neuropeps (Sleep), INSERM Institut of neuroscience
Member of Académie Nationale de Médecine (France)
Affiliation：
University of Montpellier, France
Email：
Photo：
Research Interests：
Research studies in the diagnosis, epidemiology, pathophysiology and therapy of sleep disorders related to neurological disorders including narcolepsy, hypersomnias, parasomnia, insomnia, Parkinson, Alzheimer and RLS.
Selected Publications：
h index: (Web of Science: 85),
Author or coauthor of 613 papers published in international and national peer-reviewed journals (including NEJM, Lancet, Lancet Neurol, Science, Nature Genetic),
Several review articles and book chapters in French and English: >100
Editor of three French book related to sleep medicine.
Abstract：
Hypersomnolence is a frequent multidimensional complaint with excessive daytime sleepiness, excessive quantity of sleep, and sleep inertia. It is associated with altered quality of life, accidents, and often with cardiovascular, psychiatric and neurological disorders. Many different sleep and non-sleep causes are associated with hypersomnolence. Current criteria used for presence of hypersomnolence and related disorders need to be improved and revised. The more severe causes of central disorders of hypersomnolence are narcolepsy type 1 and type 2, idiopathic hypersomnia, being orphan sleep disorders. The main pathophysiologic feature is thought to reflect a deficiency of arousal systems, rather than an overactivity of sleep systems or an imbalance between both. However, large gaps persist in our understanding of the neurobiological causes of hypersomnolence and related disorders except for narcolepsy type 1 with impaired neurotransmission of hypocretin/orexin, by a probable autoimmune process. We need to 1/ better understand what determines an individual’s sleep need and identify biomarkers for the different forms of hypersomnolence, 2/ better precise how disorders of hypersomnolence progress over the years, and 3/ better treat our patients with precision medicine.
2026年會：