講師資料
Talks：
Restoring the Night- Circadian Medicine in the Management of Insomnia
Name：
Prof. Nava Zisapel
Position：
Full professor (emeritus)
Affiliation：
Biochemistry in the Department of Neurobiology, Faculty of Life Sciences, at Tel Aviv University
Email：
Photo：
Research Interests：
Prof. Nava Zisapel is a neurobiologist, neuropharmacologist, and neurochemist whose primary research focuses on the biological clock, melatonin, and sleep regulation. Prof. Nava Zisapel has authored over 200 original research papers and reviews. Below are notable publications of her research relating to Circadin:
Selected Publications：
1. Zisapel, N. (2018). New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. British Journal of Pharmacology, 175(16), 3190–3199.
2. Wade, A. G., Ford, I., Crawford, G., McMahon, A. D., Nir, T., Laudon, M., & Zisapel, N. (2007). Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes. Current Medical Research and Opinion, 23(10), 2597–2605.
3. Lemoine, P., Nir, T., Laudon, M., & Zisapel, N. (2007). Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. Journal of Sleep Research, 16(4), 372–380.
4. Garfinkel D, Laudon M, Nof D, Zisapel N. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet. 1995 Aug 26;346(8974):541-4.
5. Haimov I, Laudon M, Zisapel N, Souroujon M, Nof D, Shlitner A, Herer P, Tzischinsky O, Lavie P. Sleep disorders and melatonin rhythms in elderly people. BMJ. 1994 Jul 16;309(6948):167.
Abstract：
Sleep is a vital, active, restorative process for the body and mind. The physiological sleep-wake cycle relies on the interaction between homeostatic sleep pressure accumulating during wake (Process S) and the 24-hour circadian clock alerting signal (Process C). As night falls, the pineal gland releases melatonin, the biological signal of darkness, which has two main effects: it dampens the circadian clock's alerting signal to promote sleep and adjusts the clock phase to align the 24-hour sleep-wake cycle, with the day-night cycle. Chronic circadian disruption degrades sleep quality, which correlates directly with long-term cardiovascular, metabolic, cognitive, and mental health risks.
Insomnia is dissatisfaction with the amount and/or quality of sleep that is associated with significant daytime distress. Managing insomnia in adults aged 55 and older requires solutions that avoid traditional sedative risks like memory loss, falls, dependence, and daytime grogginess. Prolonged-release melatonin (Circadin®) addresses this by gradually releasing melatonin to mirror the body's physiological nocturnal secretion profile. By aligning with sleep promoting and physiological circadian mechanisms, it facilitates sleep onset, enhances the restorative quality of sleep, preserves critical sleep architecture (SWS and REM), and improves next-day alertness without compromising memory or physical stability and without risk of tolerance, dependence, and rebound insomnia.
Altogether, Circadin® is the result of a new way of thinking about sleep-wake disorders addressing circadian medicine in the management of insomnia with important impact on morning alertness. Long term efficacy and safety data support its use for insomnia in the 55 and older population.
2026年會：