講師資料
Talks：
Tonsil Microbiome among Obstructive Sleep Apnea Children across Intermittent Hypoxemia and Body Weight Status
Name：
莊海華(Hai-Hua Chuang)
Position：
1. Associate Professor
2. Department Director
3. PhD. Candidate
Affiliation：
1. Department of Family Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
2. College of Medicine, Chang Gung University, Taoyuan, Taiwan
3. School of Medicine, National Tsing Hua University, Hsinchu, Taiwan
4. Health Promotion Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
5. Department of Industrial Engineering and Management, National Taipei University of Technology, Taipei, Taiwan
Email：
Photo：
Research Interests：
Epidemiology, health impact, and prevention of obesity, suboptimal body composition, and declined physical fitness
Selected Publications：
1. Cheng, K. H., Wu, N. K., Chen, C. T., Hsu, C. Y., Lin, Y. A., Luo, J. J-C., Lee, L. A., Chuang, H. H.* Effectiveness and Response Differences of a Multidisciplinary Workplace Health Promotion Program for Healthcare Workers. Frontiers in Medicine. 7, 2022, 9, 930165. (SCI；IF 2021=5.058；MEDICINE, GENERAL & INTERNAL: 52/172=30.2, Q2)
2. Chuang, H.H., Wang, C. Y., Chuang, L. P., Huang, Y. S., Li, H. Y., Fang, T. J., Lin, R. H., & Lee, L. A.* The 3% Oxygen Desaturation Index is an Independent Risk Factor for Hypertension Among Children with Obstructive Sleep Apnea. Nature and Science of Sleep. 6, 2022, 14, 1149-1164. (SCI；IF 2020=5.346；CLINICAL NEUROLOGY: 40/208=19.2, Q1)
3. Hsu, W. C., Lin Y. C., Chuang, H. H., Yen, K. Y., Chen, W. P., & Ro, L. S.* A Muscle Biosignature Differentiating Between Limb-Girdle Muscular Dystrophy and Idiopathic Inflammatory Myopathy on Magnetic Resonance Imaging. Frontiers in Neurology. 12, 2021, 12, 783095. (SCI；IF 2021=4.086；CLINICAL NEUROLOGY: 88/212=41.5, Q2)
4. Chao, Y. P., Chuang, H. H., Hsin, L. J., Kang, C. J., Fang, T. J., Li, H. Y., Huang, C. G., Kuo, T. B. J., Yang, C. H., Shyu, H. Y., Wang, S. L., Shyu, L. Y., & Lee, L. A.* Using A 360° Virtual Reality or Two-Dimensional Video to Learn History Taking and Physical Examination Skills: A Pilot System-Design Study. JMIR Serious Games. 11, 2021, 9(4), e13124. (SCI；IF 2020=4.413；HEALTH CARE SCIENCES & SERVICES: 25/107=23.4, Q1)
5. Lin, Y. U., Chuang, H. H., Lo, L. M., & Chiou, H. I. Mental health. Taiwan Journal of Public Health. 10, 2021, 40(5), 459-461.
6. Chuang, H. H., Hsu, J. F., Wang, C. Y., Chuang, L. P, Chen, M. C., Chen, N. H., Huang, Y. S., Li, H. Y., & Lee, L. A.* Hypertension in Children with Obstructive Sleep Apnea Syndrome—Age, Weight Status, and Disease Severity. International Journal of Environmental Research and Public Health. 9, 2021, 18(18), 9602. (SSCI；IF 2021= 4.614；PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH: 45/182=24.7, Q1)
7. Huang, S. W., Liou, J. J. H*., Chuang, H. H., Ma, J. C. Y., Lin, C. S., & Tzeng, G. H. Exploring the Key Factors for Preventing Public Health Crises Under Incomplete Information. International Journal of Fuzzy Systems. 8, 2021, 23(8), 2467-2488. (SCI；IF 2020=4.673；COMPUTER SCIENCE, INFORMATION SYSTEMS: 35/161=21.7, Q1)
8. Chuang, H. H., Liu, C. H., Wang, C. Y., Lo, Y. L., Lee, G. S., Chao, Y. P., Li, H.Y., Kuo, T. B-J., Yang, C. C-H., Shyu, L. Y., Lee, A. L.* Snoring Sound Characteristics Are Associated with Common Carotid Artery Profiles in Patients with Obstructive Sleep Apnea. Nature and Science of Sleep. 7, 2021, 13, 1243-1255. (SCI；IF 2020=5.346；CLINICAL NEUROLOGY: 40/208=19.2, Q1) [長庚醫院優秀論文獎]
Abstract：
The tonsil microbiome is associated with chronic tonsillitis and obstructive sleep apnea (OSA) in children, and the gut microbiome is associated with host weight status. In this study, we hypothesized that weight status may be associated with clinical profiles and the tonsil microbiome in children with OSA. We prospectively enrolled 33 non-healthy-weight (cases) and 33 healthy-weight (controls) pediatric OSA patients matched by the proportion of chronic tonsillitis. Differences in the tonsil microbiome between the non-healthy-weight and healthy-weight subgroups and relation- ships between the tonsil microbiome and clinical variables were investigated. Non-healthy weight was associated with significant intermittent hypoxemia (oxygen desaturation index, mean blood saturation (SpO2), and minimal SpO2) and higher systolic blood pressure percentile, but was not related to the tonsil microbiome. However, chronic tonsillitis was related to Acidobacteria in the non-healthy-weight subgroup, and oxygen desaturation index was associated with Bacteroidetes in the healthy-weight subgroup. In post hoc analysis, the children with mean SpO2 ≤ 97% had reduced α and β diversities and a higher abundance of Bacteroidetes than those with mean SpO2 > 97%. These preliminary findings are novel and provide insights into future research to understand the pathogenesis of the disease and develop personalized treatments for pediatric OSA.