講師資料
Talks：
Coordinated timing among multiple circadian clocks
Name：
明智煥(Jihwan Myung)
Position：
Associate Professor
Affiliation：
Graduate Institute of Mind, Brain and Consciousness (GIMBC), Taipei Medical University
Email：
Photo：
Research Interests：
Circadian biology
Selected Publications：
1. Myung J, Wu MY, Lee CY, Rahim AR, Truong VH, Wu D, Piggins HD, Wu MS (2019). The kidney clock contributes to timekeeping by the master circadian clock. Int. J. Mol. Sci. 20: 2765.
2. Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T (2018). The choroid plexus is an important circadian clock component. Nat. Commun. 9: 1062.
3. Myung J, Hong S, DeWoskin D, De Schutter E, Forger DB, Takumi T (2015). GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time. Proc. Natl. Acad. Sci. USA. 112: E3920-E3929.
Abstract：
A spontaneous organization of clock network emerges via communication among cellular circadian oscillators. The organization of clock phases is comparable to network memory in the sense that the pattern is retained and is plastic subject to the photoperiodic light condition and the developmental stage. This pattern of coordinated timing, which we call the phase organization, can be understood as encoded memory of a daylength. Both the mechanism and function of the phase organization remain unknown, but a simple and elegant mathematical description of its formation can be achieved if we allow “negative” coupling among phase oscillators.