講師資料
Talks：
Current theory and literature review of gastroesophageal reflux and dysphagia in sleep disorders
Name：
盧柏文(Po-Wen Lu)
Position：
Attending Physician of Gastroenterology Department of Shuanghe Hospital
Affiliation：
1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taiwan. No.291, Zhongzheng Rd., Zhonghe, Taipei 23561, Taiwan, ROC
2. Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei 11052, Taiwan, ROC
Email：
Photo：
Research Interests：
1. Gastrointestinal motility and functional diseases.
2. Development of endoscopic hemostatic devices and materials.
3. Research on the diagnosis and treatment of pylori.
Selected Publications：
1. Diogo Turiani Hourneaux de Moura, Amit H Sachdev, Po-Wen Lu, Igor Braga Ribeiro, Christopher C Thompson. Acute bleeding after argon plasma coagulation for weight regain after gastric bypass: A case report. World J Clin Cases. Aug 6, 2019; 7(15): 2038-2043
2. Ahmad Najdat Bazarbashi , Diogo Turiani Hourneaux de Moura, Po-Wen Lu, Amitabh Srivastava, Christopher C Thompson, Hiroyuki Aihara. Endoscopic submucosal dissection of esophageal metastatic melanoma. VideoGIE. 2019 Nov; 4(11): 501–504
3. Lu, Po-Wen; Chen, Chien-Chuan; Wu, Jia-Feng; Lee, Hui-Chuan; Lee, Yi-Chia; Wang, Hsiu-Po; Wu, Ming-Shiang; Tseng, Ping-Huei. Clinical characteristics and associated psychosocial dysfunction in patients with functional dysphagia: a study based on high-resolution impedance manometry and Rome IV criteria. Clinical and Translational Gastroenterology: June 08, 2022
Abstract：
Gastroesophageal reflux (GERD) is associated with ENT disorders and symptoms and is another risk factor for obstructive sleep apnea syndrome (OSAS). Gastric emptying during sleep was delayed, esophageal clearance was significantly delayed, and upper esophageal sphincter pressure was significantly reduced. Studies have linked OSAS with a high frequency of GERD, resulting from increased intrathoracic pressure, further contributing to acid reflux episodes. Severe progression of OSAS also promotes acid reflux, leading to inflammation and even obstruction of the upper airways. In numerous studies over the past decade, continuous positive airway pressure (CPAP) therapy has been found to improve sleep quality in patients with OSAHS and has been shown to improve reflux. And a recent meta-analysis evaluating the evidence for the relationship between hydrogen ion pump inhibitor (PPI) therapy (GERD) and improvement in obstructive sleep apnea (OSA) found that this approach may improve nighttime sleep quality. In addition, more studies are using polysomnography to record apnea index and 24-hour pH monitoring to record the frequency of acid reflux and GERD in OSAS patients; additionally, GERD symptoms are also associated with worsening sleep quality.