Talks：

Phenotyping Pediatric OSA: Step towards Personalized Medicine

Name：

Umakanth Katwa, MD

Position：

Director, Sleep Laboratory

Affiliation：

Harvard Medical School Boston Children’s Hospital

Email：

Umakanth.katwa@childrens.harvard.edu

Photo：

Research Interests：

Phenotyping Pediatric Sleep Apnea Disorders of respiratory control

Selected Publications：

◆ Rosen R, Amirault J, Johnston N, Haver K, Khatwa U, Rubinstein E, Nurko S.The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing. Pediatr Pulmonol. 2014 Nov;49(11):1090-6 ◆ Khwaja OS, Ho E, Barnes KV, O'Leary HM, Pereira LM, Finkelstein Y, Nelson CA 3rd, Vogel-Farley V, DeGregorio G, Holm IA, Khatwa U, Kapur K, Alexander ME, Finnegan DM, Cantwell NG, Walco AC, Rappaport L, Gregas M, Fichorova RN, Shannon MW, Sur M, Kaufmann WE. Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12): ◆ Rosen R, Amirault J, Heinz N, Litman H, Khatwa U. The sensitivity of acoustic cough recording relative to intraesophageal pressure recording and patient report during reflux testing. Neurogastroenterol Motil. 2014 Nov;26(11):1635-41 ◆ Rosen R, Amirault J, Liu H, Mitchell P, Hu L, Khatwa U, Onderdonk A. Changes in gastric and lung microflora with acid suppression: acid suppression and bacterial growth. JAMA Pediatr. 2014 Oct; 168(10):932-7 ◆ Yeung JC, Katwa UA, Lee GS. Sleep Disordered Breathing in Bardet Biedel Syndrome. Inter J Pediatr Otolarygo 2017 Nov;102:127-132 ◆ Khatwa UA, Dy FJ. Pulmonary Manifestations of Neuromuscular Diseases.Indian J Pediatr. 2015 Sep; 82 (9):841-51

Abstract：

Pediatric sleep apnea is increasingly recognized in children as a major concern for sleep disturbances and developmental concerns. Due to awareness of importance of sleep in young children, many are screened and diagnosed as obstructive sleep apnea, however given the burden of this problem not many institutes have facilities to evaluate for pediatric sleep disordered breathing. Although the treatment of choice in children is adeno-tonsillectomy, there is relatively high incidence of residual disease. Although other treatment options exits there appears to be lack of consensus in among many about the other treatment options in children. Precise phenotyping is crucial to understand involved etiological and comorbid factors which help to develop an individualized treatment plan. In this talk the speaker will discuss the various aspect of precise phenotyping OSA in children.